CKDdb-logoCKDdb - Molecule ID A0245

geneNGFR, TNFRSF16
nameTumor necrosis factor receptor superfamily member 16 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TNR16_HUMANP08138ENSG000000643004804Hs.415768162010

Functions and classifications

GOC:cell surface, C:cytosol, C:endosome, C:extracellular region, C:integral component of plasma membrane, C:nucleoplasm, F:death receptor activity, F:Rab GTPase binding, F:transmembrane signaling receptor activity, P:apoptotic signaling pathway, P:axon guidance, P:central nervous system development, P:detection of temperature stimulus, P:extrinsic apoptotic signaling pathway via death domain receptors, P:glucose homeostasis, P:hair follicle morphogenesis, P:intracellular protein transport, P:membrane protein intracellular domain proteolysis, P:negative regulation of apoptotic process, P:negative regulation of axonogenesis, P:negative regulation of cell cycle, P:negative regulation of fibroblast growth factor receptor signaling pathway, P:negative regulation of hair follicle development, P:nerve development, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of apoptotic signaling pathway, P:positive regulation of axonogenesis, P:positive regulation of fibroblast proliferation, P:positive regulation of odontogenesis of dentin-containing tooth, P:regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:regulation of gene expression, P:regulation of glucose import in response to insulin stimulus, C:cytoplasm, C:plasma membrane, C:integral to plasma membrane, P:apoptotic process, P:induction of apoptosis, P:negative regulation of muscle organ development, P:nerve growth factor receptor signaling pathway, P:response to wounding, P:skin development, C:nucleus
UniProt3D-structure, Apoptosis, Complete proteome, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Membrane, Neurogenesis, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Repeat, Signal, Transmembrane, Transmembrane helix
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.460.0141RNA microarray19698090
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)4.16.20E-10LC-MS25150443
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)2.350.00667nanoLC-ESI-MS/MS25666440
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.148.30E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium