CKDdb-logoCKDdb - Molecule ID A0242

geneCAV1, CAV, MSTP085
nameCaveolin-1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAV1_HUMANQ03135ENSG00000105974857Hs.74034601047, 612526, 615343

Functions and classifications

GOC:acrosomal membrane, C:apical plasma membrane, C:basolateral plasma membrane, C:caveola, C:cell cortex, C:cilium, C:endocytic vesicle membrane, C:endoplasmic reticulum, C:endosome, C:Golgi membrane, C:integral component of plasma membrane, C:lipid particle, C:perinuclear region of cytoplasm, C:protein complex, F:cholesterol binding, F:patched binding, F:peptidase activator activity, F:protein complex scaffold, P:angiogenesis, P:apoptotic signaling pathway, P:blood coagulation, P:calcium ion transport, P:caveola assembly, P:caveolin-mediated endocytosis, P:cellular response to hyperoxia, P:cellular response to starvation, P:cholesterol homeostasis, P:cholesterol transport, P:cytosolic calcium ion homeostasis, P:inactivation of MAPK activity, P:lactation, P:leukocyte migration, P:lipid storage, P:maintenance of protein location in cell, P:mammary gland involution, P:MAPK cascade, P:membrane depolarization, P:negative regulation of anoikis, P:negative regulation of BMP signaling pathway, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cytokine-mediated signaling pathway, P:negative regulation of endothelial cell proliferation, P:negative regulation of epithelial cell differentiation, P:negative regulation of JAK-STAT cascade, P:negative regulation of nitric oxide biosynthetic process, P:negative regulation of nitric-oxide synthase activity, P:negative regulation of peptidyl-serine phosphorylation, P:negative regulation of protein binding, P:negative regulation of protein ubiquitination, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of tyrosine phosphorylation of Stat5 protein, P:nitric oxide homeostasis, P:nitric oxide metabolic process, P:positive regulation of calcium ion transport into cytosol, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of metalloenzyme activity, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of vasoconstriction, P:protein homooligomerization, P:receptor internalization involved in canonical Wnt signaling pathway, P:regulation of blood coagulation, P:regulation of fatty acid metabolic process, P:regulation of nitric-oxide synthase activity, P:regulation of smooth muscle contraction, P:regulation of the force of heart contraction by chemical signal, P:response to calcium ion, P:response to estrogen, P:response to hypoxia, P:response to ischemia, P:response to progesterone, P:skeletal muscle tissue development, P:small molecule metabolic process, P:T cell costimulation, P:triglyceride metabolic process, P:vasculogenesis, P:vasoconstriction, P:vesicle organization, P:viral process, P:cellular calcium ion homeostasis, P:protein localization, C:basal plasma membrane, C:cell surface, C:cytosol, C:flagellum, C:focal adhesion, C:integral to plasma membrane, C:mitochondrion, P:cholesterol efflux, P:microtubule polymerization, P:negative regulation of canonical Wnt receptor signaling pathway, P:positive regulation of canonical Wnt receptor signaling pathway, P:positive regulation of endocytosis, P:positive regulation of microtubule polymerization, P:receptor internalization involved in canonical Wnt receptor signaling pathway, P:response to drug, P:response to estrogen stimulus, P:response to gamma radiation, P:response to glucocorticoid stimulus, P:response to mechanical stimulus, P:response to nutrient, P:response to progesterone stimulus, P:virus-host interaction, P:positive regulation of signal transduction
UniProtAcetylation, Alternative initiation, Cell membrane, Complete proteome, Congenital generalized lipodystrophy, Direct protein sequencing, Disease mutation, Golgi apparatus, Host-virus interaction, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Reference proteome
PADBscaffolder, docking, adaptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)3.010.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.340.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.820.0148729RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.69< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.93< 0.05RNA microarray21752957
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)0.98< 0.05LC-MS/MS24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)0.51< 0.05LC-MS/MS24927646
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.250.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium