CKDdb-logoCKDdb - Molecule ID A023F

geneAsns
nameAsparagine synthetase [glutamine-hydrolyzing]
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASNS_MOUSEQ61024ENSMUSG0000002975227053Mm.2942108370

Functions and classifications

GOF:asparagine synthase (glutamine-hydrolyzing) activity, F:ATP binding, F:cofactor binding, P:cellular response to glucose starvation, P:cellular response to hormone stimulus, P:glutamine metabolic process, P:L-asparagine biosynthetic process, P:liver development, P:negative regulation of apoptotic process, P:positive regulation of mitotic cell cycle, P:response to amino acid, P:response to follicle-stimulating hormone, P:response to light stimulus, P:response to mechanical stimulus, P:response to methotrexate, P:response to toxic substance, F:asparagine synthase (glutamine-hydrolyzing) activity, F:cofactor binding, P:asparagine biosynthetic process, P:cellular response to glucose starvation, P:cellular response to hormone stimulus, P:liver development, P:negative regulation of apoptotic process, P:positive regulation of mitotic cell cycle, P:response to amino acid, P:response to follicle-stimulating hormone, P:response to light stimulus, P:response to mechanical stimulus, P:response to methotrexate, P:response to toxic substance, F:asparagine synthase (glutamine-hydrolyzing) activity, F:ATP binding, P:L-asparagine biosynthetic process, F:asparagine synthase (glutamine-hydrolyzing) activity, F:cofactor binding, P:asparagine biosynthetic process, P:cellular response to glucose starvation, P:cellular response to hormone stimulus, P:liver development, P:negative regulation of apoptotic process, P:positive regulation of mitotic cell cycle, P:response to amino acid, P:response to follicle-stimulating hormone, P:response to light stimulus, P:response to mechanical stimulus, P:response to methotrexate, P:response to toxic substance,
UniProtAcetylation, Amino-acid biosynthesis, Asparagine biosynthesis, ATP-binding, Complete proteome, Glutamine amidotransferase, Ligase, Nucleotide-binding, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.790.04cDNA microarray19099603
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.182.79E-07RNA microarray20813037
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.80cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.340cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)6.61< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.34< 0.05RNA microarray21752957
Exp23291264aRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)4.140.0007017RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)18.490.00000117RNA microarray23291264
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.050.00000369RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium