CKDdb-logoCKDdb - Molecule ID A0234

geneActr3
nameActin-related protein 3
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARP3_MOUSEQ99JY9ENSMUSG0000002634174117Mm.183102604222

Functions and classifications

GOC:cell-cell junction, C:excitatory synapse, C:Golgi membrane, C:hemidesmosome, C:lamellipodium, C:podosome, F:ATP binding, F:protein binding, P:asymmetric cell division, P:cilium morphogenesis, P:establishment or maintenance of cell polarity, P:meiotic cell cycle, P:meiotic cytokinesis, P:positive regulation of actin filament polymerization, P:positive regulation of dendrite morphogenesis, P:positive regulation of filopodium assembly, P:positive regulation of lamellipodium assembly, P:positive regulation of neuron differentiation, P:regulation of myosin II filament organization, P:response to antibiotic, P:response to carbohydrate, P:spindle localization, C:cytoplasm, C:cytoskeleton, P:cytokinesis after meiosis, P:regulation of actin filament polymerization, C:actin filament, P:response to carbohydrate stimulus
UniProtAcetylation, Actin-binding, ATP-binding, Cell projection, Cilium biogenesis/degradation, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Nucleotide-binding, Reference proteome
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.8< 0.05RNA microarray18187931
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0.3< 0.05MALDI-TOF-MS19688724
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.2< 0.05LC-MS/MS19845401
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.99< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.54< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.65< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.372.83E-06RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.41.16E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.418.28E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium