CKDdb-logoCKDdb - Molecule ID A0233

geneARPC2, ARC34, PRO2446
nameARP2/3 complex 34 kDa subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARPC2_HUMANO15144ENSP0000029568510109Hs.529303604224

Functions and classifications

GOC:Arp2/3 protein complex, C:cell leading edge, C:cell projection, C:cytosol, C:endosome, C:focal adhesion, C:Golgi apparatus, C:plasma membrane, F:structural constituent of cytoskeleton, P:cellular component movement, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, P:positive regulation of actin filament polymerization, P:positive regulation of substrate adhesion-dependent cell spreading, C:cytoskeleton, P:regulation of actin filament polymerization
UniProtAcetylation, Actin-binding, Cell junction, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Reference proteome, Synapse, Synaptosome
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)4.959 +/- 1.064< 0.05RNA microarray18354378
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)3.233.20E-04Nano RP-LC, MALDI-TOF22061828
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.990.005325151LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium