CKDdb-logoCKDdb - Molecule ID A0232

geneARPC3, ARC21
nameARP2/3 complex 21 kDa subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARPC3_HUMANO15145ENSG0000011122910094Hs.524741604225

Functions and classifications

GOC:Arp2/3 protein complex, C:cytosol, C:lamellipodium, F:structural constituent of cytoskeleton, P:Arp2/3 complex-mediated actin nucleation, P:cellular component movement, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, C:cytoplasm, P:regulation of actin filament polymerization, C:cytoskeleton
UniProtAcetylation, Actin-binding, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Phosphoprotein, Reference proteome
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.290.000000112RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.873.23E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)6.47< 0.05RNA microarray21752957
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)0.96< 0.05LC-MS/MS24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)0.58< 0.05LC-MS/MS24927646
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.491.46E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium