CKDdb-logoCKDdb - Molecule ID A0219

geneCDH2, CDHN, NCAD
nameNeural-cadherin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CADH2_HUMANP19022ENSG000001705581000Hs.464829114020

Functions and classifications

GOC:apical plasma membrane, C:catenin complex, C:cell-cell adherens junction, C:fascia adherens, C:integral component of membrane, C:intercalated disc, C:lamellipodium, C:synapse, F:beta-catenin binding, F:calcium ion binding, P:adherens junction organization, P:blood vessel morphogenesis, P:calcium-dependent cell-cell adhesion, P:cell adhesion, P:cell junction assembly, P:cell migration, P:heterophilic cell-cell adhesion, P:homophilic cell adhesion, P:muscle cell differentiation, P:negative regulation of canonical Wnt signaling pathway, P:positive regulation of MAPK cascade, P:positive regulation of muscle cell differentiation, P:striated muscle cell differentiation, C:plasma membrane, C:membrane, C:integral to membrane, C:synapse part, P:negative regulation of canonical Wnt receptor signaling pathway, P:regulation of axonogenesis, P:regulation of myelination, P:regulation of protein localization, P:regulation of Rho protein signal transduction, P:synapse assembly, C:protein complex, F:phospholipid binding
UniProtCalcium, Cell adhesion, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Glycoprotein, Membrane, Metal-binding, Polymorphism, Reference proteome, Repeat, Signal, Transmembrane, Transmembrane helix
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.00593RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.531.25E-05RNA microarray20019191
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)2.31< 0.05LC-MS/MS20639044
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)12.990.0008RNA microarray20847290
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)2.92.15E-49NGS, RNA-seq.22266139
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)0.650.01885LC-MS/MS23228063
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.10.00000139RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.220.000285RNA microarray23291264
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)1000 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)1000 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.44 1DE, MALDI24096133
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.19.60E-07LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium