CKDdb-logoCKDdb - Molecule ID A0197

geneBCL2, bcl-2
nameApoptosis regulator Bcl-2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BCL2_HUMANP10415ENSG00000171791596Hs.150749151430

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:mitochondrial outer membrane, C:myelin sheath, C:nuclear membrane, C:pore complex, F:channel activity, F:channel inhibitor activity, F:protease binding, F:sequence-specific DNA binding, P:actin filament organization, P:axon regeneration, P:axonogenesis, P:B cell homeostasis, P:B cell lineage commitment, P:B cell proliferation, P:B cell receptor signaling pathway, P:behavioral fear response, P:branching involved in ureteric bud morphogenesis, P:CD8-positive, alpha-beta T cell lineage commitment, P:cell aging, P:cell growth, P:cell-cell adhesion, P:cellular response to glucose starvation, P:cellular response to hypoxia, P:cellular response to organic substance, P:cochlear nucleus development, P:defense response to virus, P:developmental growth, P:digestive tract morphogenesis, P:ear development, P:endoplasmic reticulum calcium ion homeostasis, P:extrinsic apoptotic signaling pathway in absence of ligand, P:extrinsic apoptotic signaling pathway via death domain receptors, P:female pregnancy, P:focal adhesion assembly, P:gland morphogenesis, P:glomerulus development, P:hair follicle morphogenesis, P:homeostasis of number of cells within a tissue, P:humoral immune response, P:innate immune response, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, P:intrinsic apoptotic signaling pathway in response to oxidative stress, P:lymphoid progenitor cell differentiation, P:male gonad development, P:melanin metabolic process, P:melanocyte differentiation, P:mesenchymal cell development, P:metanephros development, P:negative regulation of anoikis, P:negative regulation of autophagy, P:negative regulation of calcium ion transport into cytosol, P:negative regulation of cell growth, P:negative regulation of cell migration, P:negative regulation of cellular pH reduction, P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:negative regulation of G1/S transition of mitotic cell cycle, P:negative regulation of intrinsic apoptotic signaling pathway, P:negative regulation of mitochondrial depolarization, P:negative regulation of mitotic cell cycle, P:negative regulation of myeloid cell apoptotic process, P:negative regulation of neuron apoptotic process, P:negative regulation of ossification, P:negative regulation of osteoblast proliferation, P:negative regulation of retinal cell programmed cell death, P:neuron apoptotic process, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:oocyte development, P:organ growth, P:ossification, P:ovarian follicle development, P:peptidyl-serine phosphorylation, P:peptidyl-threonine phosphorylation, P:pigment granule organization, P:positive regulation of B cell proliferation, P:positive regulation of catalytic activity, P:positive regulation of cell growth, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of melanocyte differentiation, P:positive regulation of multicellular organism growth, P:positive regulation of neuron maturation, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of skeletal muscle fiber development, P:positive regulation of smooth muscle cell migration, P:post-embryonic development, P:protein dephosphorylation, P:protein polyubiquitination, P:reactive oxygen species metabolic process, P:regulation of calcium ion transport, P:regulation of cell-matrix adhesion, P:regulation of glycoprotein biosynthetic process, P:regulation of mitochondrial membrane permeability, P:regulation of mitochondrial membrane potential, P:regulation of nitrogen utilization, P:regulation of protein heterodimerization activity, P:regulation of protein homodimerization activity, P:regulation of protein stability, P:regulation of transmembrane transporter activity, P:regulation of viral genome replication, P:release of cytochrome c from mitochondria, P:renal system process, P:response to acid, P:response to cytokine, P:response to drug, P:response to gamma radiation, P:response to glucocorticoid, P:response to hydrogen peroxide, P:response to iron ion, P:response to ischemia, P:response to nicotine, P:response to radiation, P:response to toxic substance, P:response to UV-B, P:spleen development, P:T cell differentiation in thymus, P:T cell homeostasis, P:thymus development, C:membrane, P:negative regulation of apoptotic process, C:mitochondrial membrane, P:cell proliferation, P:negative regulation of apoptotic signaling pathway, P:positive regulation of cell proliferation, P:regulation of protein localization, P:G1/S transition of mitotic cell cycle, P:glial cell apoptotic process, P:oligodendrocyte differentiation, P:organ morphogenesis, P:response to aluminum ion, P:response to caffeine, P:response to copper ion, P:response to corticosterone stimulus, P:response to cytokine stimulus, P:response to DNA damage stimulus, P:response to estrogen stimulus, P:response to ethanol, P:response to folic acid, P:response to heat, P:response to hypoxia, P:response to insulin stimulus, P:response to L-ascorbic acid, P:response to toxin
UniProt3D-structure, Alternative splicing, Apoptosis, Chromosomal rearrangement, Complete proteome, Disease mutation, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Transmembrane, Transmembrane helix, Ubl conjugation
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0000263RNA microarray19698090
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)2.880.0244RNA microarray20847290
Exp23809614aHomo sapiens83bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)4.23.77E-13RNA microarray23809614
Exp23809614bHomo sapiens32bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)6.591.67E-13RNA microarray23809614

Compile date 08-10-2018© iMODE-CKD consortium