CKDdb-logoCKDdb - Molecule ID A0167

geneARHGEF28, RGNEF
nameRHO-Guanine nucleotide exchange factor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARG28_HUMANQ8N1W1ENSG0000021494464283Hs.482521612790

Functions and classifications

GOC:cytoplasm, C:microtubule cytoskeleton, C:plasma membrane, F:metal ion binding, F:Rho guanyl-nucleotide exchange factor activity, F:RNA binding, P:cell differentiation, P:intracellular signal transduction, P:regulation of Rho GTPase activity, P:central nervous system neuron axonogenesis, P:neurofilament cytoskeleton organization, F:phospholipid binding, P:regulation of Rho protein signal transduction, C:intracellular
UniProtAlternative splicing, Cell membrane, Coiled coil, Complete proteome, Cytoplasm, Differentiation, Guanine-nucleotide releasing factor, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, RNA-binding, Zinc, Zinc-finger
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.00878RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.557.14E-06RNA microarray20019191
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)3.220.0361484RNA microarray23935909
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.940.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium