CKDdb-logoCKDdb - Molecule ID A0160

geneC-CBL, CBL, CBL2
nameE3 ubiquitin-protein ligase CBL
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CBL_HUMANP22681ENSG00000110395867Hs.504096165360, 613563

Functions and classifications

GOC:cytosol, C:flotillin complex, C:nucleus, C:plasma membrane, F:calcium ion binding, F:sequence-specific DNA binding transcription factor activity, F:signal transducer activity, F:ubiquitin-protein ligase activity, F:zinc ion binding, P:epidermal growth factor receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:negative regulation of apoptotic process, P:negative regulation of epidermal growth factor receptor signaling pathway, P:positive regulation of phosphatidylinositol 3-kinase signaling, P:positive regulation of receptor-mediated endocytosis, P:positive regulation of phosphatidylinositol 3-kinase cascade
UniProt3D-structure, Acetylation, Calcium, Cell membrane, Complete proteome, Cytoplasm, Disease mutation, Ligase, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Repeat, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.351.06E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium