CKDdb-logoCKDdb - Molecule ID A015B

geneSMAD6, MADH6
nameMothers against decapentaplegic homolog 6
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SMAD6_HUMANO43541ENSG000001378344091Hs.153863602931, 614823

Functions and classifications

GOC:cytosol, C:nucleus, C:transcription factor complex, F:chromatin binding, F:metal ion binding, F:sequence-specific DNA binding transcription factor activity, F:transcription regulatory region DNA binding, F:transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity, F:type I activin receptor binding, F:type I transforming growth factor beta receptor binding, P:BMP signaling pathway, P:cell-substrate adhesion, P:immune response, P:negative regulation of apoptotic process, P:negative regulation of BMP signaling pathway, P:negative regulation of cell proliferation, P:negative regulation of pathway-restricted SMAD protein phosphorylation, P:negative regulation of SMAD protein complex assembly, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:response to estrogen, P:response to laminar fluid shear stress, P:transcription, DNA-templated, P:transforming growth factor beta receptor signaling pathway, P:ureteric bud development, P:zygotic specification of dorsal/ventral axis, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of S phase of mitotic cell cycle, P:response to estrogen stimulus, P:transcription, DNA-dependent
UniProtAlternative splicing, Complete proteome, Disease mutation, DNA-binding, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Transcription, Transcription regulation, Ubl conjugation, Zinc
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.11< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.65< 0.05cDNA microarray17003339
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.440.0369565RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.210.00182RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.00397RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.430.0339RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.1< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)3.520.0000108RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium