CKDdb-logoCKDdb - Molecule ID A0127

geneABI1, SSH3BP, SSH3BP1
nameSpectrin SH3 binding protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABI1_HUMANQ8IZP0ENSP0000027959910006Hs.508148603050

Functions and classifications

GOC:cell junction, C:cytoskeleton, C:cytosol, C:endoplasmic reticulum, C:filopodium, C:growth cone, C:lamellipodium, C:nucleus, C:synapse, F:cytoskeletal protein binding, F:protein tyrosine kinase activator activity, P:actin polymerization or depolymerization, P:cellular component movement, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, P:lamellipodium morphogenesis, P:megakaryocyte development, P:negative regulation of cell proliferation, P:peptidyl-tyrosine phosphorylation, P:somitogenesis, P:transmembrane receptor protein tyrosine kinase signaling pathway, C:cytoplasm, P:positive regulation of protein tyrosine kinase activity
UniProtAcetylation, Alternative splicing, Cell junction, Cell membrane, Cell projection, Chromosomal rearrangement, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Membrane, Nucleus, Phosphoprotein, Polymorphism, Postsynaptic cell membrane, Reference proteome, SH3 domain, Synapse, Synaptosome
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 3.48< 0.05RNA microarray  21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.31< 0.05RNA microarray  21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.381.54E-05RNA microarray  26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.473.69E-04RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium