CKDdb-logoCKDdb - Molecule ID A0125

geneCask
namePeripheral plasma membrane protein CASK
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CSKP_RATQ62915ENSRNOG0000003975929647Rn.72627300172, 300422, 300749

Functions and classifications

GOC:ciliary membrane, C:cytoplasm, C:cytosol, C:dendrite, C:membrane, C:nucleus, C:plasma membrane, C:presynaptic membrane, C:protein complex, C:synaptic membrane, F:ATP binding, F:calmodulin binding, F:calmodulin-dependent protein kinase activity, F:neurexin family protein binding, F:PDZ domain binding, F:protein binding, F:protein C-terminus binding, F:protein complex binding, F:transcription coactivator activity, P:intracellular protein transport, P:protein complex assembly, P:regulation of RNA biosynthetic process, C:cilium membrane, C:integral component of membrane, F:G-protein coupled receptor activity, C:integral to membrane, F:G-protein coupled purinergic nucleotide receptor activity, C:basement membrane, C:basolateral plasma membrane, C:cell-cell junction, C:nuclear lamina, C:nuclear matrix, C:nucleolus, C:synapse, P:calcium ion import, P:negative regulation of cell-matrix adhesion, P:negative regulation of cellular response to growth factor stimulus, P:negative regulation of keratinocyte proliferation, P:negative regulation of wound healing, P:positive regulation of calcium ion import, P:positive regulation of transcription from RNA polymerase II promoter, F:protein kinase activity
UniProt3D-structure, ATP-binding, Calmodulin-binding, Cell membrane, Complete proteome, Cytoplasm, Kinase, Membrane, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Repeat, Serine/threonine-protein kinase, SH3 domain, Transferase, G-protein coupled receptor, Receptor, Transducer, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.75< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.473.15E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium