CKDdb-logoCKDdb - Molecule ID A0116

geneARRB1, ARR1
nameBeta-arrestin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARRB1_HUMANP49407ENSG00000137486408Hs.503284107940

Functions and classifications

GOC:chromatin, C:coated pit, C:cytoplasmic vesicle membrane, C:cytosol, C:Golgi membrane, C:lysosomal membrane, C:nucleus, C:plasma membrane, C:pseudopodium, F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process, F:enzyme inhibitor activity, F:GTPase activator activity, F:transcription regulatory region DNA binding, P:G-protein coupled receptor internalization, P:negative regulation of interleukin-6 production, P:negative regulation of interleukin-8 production, P:negative regulation of NF-kappaB transcription factor activity, P:negative regulation of protein ubiquitination, P:Notch signaling pathway, P:phototransduction, P:platelet activation, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of histone H4 acetylation, P:positive regulation of insulin secretion involved in cellular response to glucose stimulus, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of protein binding, P:positive regulation of protein phosphorylation, P:positive regulation of receptor internalization, P:positive regulation of Rho protein signal transduction, P:positive regulation of transcription from RNA polymerase II promoter, P:post-Golgi vesicle-mediated transport, P:proteasome-mediated ubiquitin-dependent protein catabolic process, P:protein transport, P:protein ubiquitination, P:stress fiber assembly, P:transcription from RNA polymerase II promoter, P:signal transduction, P:cellular membrane organization, P:proteasomal ubiquitin-dependent protein catabolic process
UniProt3D-structure, Alternative splicing, Cell membrane, Cell projection, Coated pit, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, Phosphoprotein, Protein transport, Reference proteome, Signal transduction inhibitor, Transcription, Transcription regulation, Transport, Ubl conjugation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)20.00451RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.343.66E-08RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium