CKDdb-logoCKDdb - Molecule ID A0111

geneARHGEF4, ASEF
nameRho guanine nucleotide exchange factor 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG4_HUMANQ9NR80ENSG0000013600250649Hs.469935605216

Functions and classifications

GOC:cytosol, C:ruffle membrane, F:Rac guanyl-nucleotide exchange factor activity, P:apoptotic signaling pathway, P:filopodium assembly, P:lamellipodium assembly, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:small GTPase mediated signal transduction, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction, P:regulation of Rho GTPase activity, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction, C:intracellular
UniProt3D-structure, Alternative splicing, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Guanine-nucleotide releasing factor, Membrane, Polymorphism, Reference proteome, SH3 domain
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.00000792RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00921RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.0302RNA microarray19698090
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.327.44E-13NGS, RNA-seq.22266139
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.180.015109RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.140.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium