CKDdb-logoCKDdb - Molecule ID A0110

geneAPC, DP2.5
nameAdenomatous polyposis coli protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APC_HUMANP25054ENSG00000134982324Hs.158932114550, 135290, 155255, 175100, 276300, 611731, 613659

Functions and classifications

GOC:adherens junction, C:axonal growth cone, C:beta-catenin destruction complex, C:centrosome, C:cytoplasmic microtubule, C:cytosol, C:kinetochore, C:lamellipodium, C:lateral plasma membrane, C:microtubule plus-end, C:nucleus, C:ruffle membrane, C:tight junction, F:microtubule plus-end binding, F:protein kinase regulator activity, P:anterior/posterior pattern specification, P:axis specification, P:axonogenesis, P:canonical Wnt signaling pathway, P:canonical Wnt signaling pathway involved in negative regulation of apoptotic process, P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process, P:cell adhesion, P:cell cycle arrest, P:cell migration, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular response to DNA damage stimulus, P:chromosome organization, P:cytoplasmic microtubule organization, P:dorsal/ventral pattern formation, P:hair follicle development, P:kidney development, P:metaphase/anaphase transition of mitotic cell cycle, P:mitotic cytokinesis, P:mitotic spindle assembly checkpoint, P:muscle cell cellular homeostasis, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cell proliferation, P:negative regulation of cyclin-dependent protein serine/threonine kinase activity, P:negative regulation of epithelial cell proliferation involved in prostate gland development, P:negative regulation of MAPK cascade, P:negative regulation of microtubule depolymerization, P:negative regulation of odontogenesis, P:positive regulation of apoptotic process, P:positive regulation of cell adhesion, P:positive regulation of cell division, P:positive regulation of cell migration, P:positive regulation of epithelial cell differentiation, P:positive regulation of microtubule polymerization, P:positive regulation of protein catabolic process, P:positive regulation of pseudopodium assembly, P:protein complex assembly, P:proximal/distal pattern formation, P:regulation of attachment of spindle microtubules to kinetochore, P:regulation of nitrogen compound metabolic process, P:regulation of osteoblast differentiation, P:regulation of osteoclast differentiation, P:retina development in camera-type eye, P:somatic stem cell maintenance, P:T cell differentiation in thymus, P:thymus development, P:tight junction assembly, C:cytoplasm, P:negative regulation of Wnt signaling pathway, P:Wnt signaling pathway, C:cell projection membrane, C:microtubule plus end, C:neuronal cell body, C:synapse, P:canonical Wnt receptor signaling pathway, P:cytokinesis after mitosis, P:establishment or maintenance of cell polarity, P:mitotic cell cycle spindle assembly checkpoint, P:mitotic metaphase/anaphase transition, P:muscle cell homeostasis, P:negative regulation of apoptotic process, P:negative regulation of canonical Wnt receptor signaling pathway, P:negative regulation of cyclin-dependent protein kinase activity, P:pancreas development, P:response to DNA damage stimulus, P:response to drug, P:skin development, P:negative regulation of Wnt receptor signaling pathway, P:Wnt receptor signaling pathway
UniProt3D-structure, Acetylation, Alternative splicing, Cell junction, Cell membrane, Cell projection, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Membrane, Microtubule, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Tumor suppressor, Ubl conjugation, Wnt signaling pathway
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.170.000000615RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.28< 0.05RNA microarray21752957
Exp23671862aMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)2.39< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp23671862bMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)0.45< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.490.0128389RNA microarray23935909
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.491.93E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium