CKDdb-logoCKDdb - Molecule ID A0020

geneBPTP-3, PTPN11, PTP2C
nameProtein-tyrosine phosphatase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PTN11_HUMANQ06124ENSG000001792955781Hs.506852151100, 156250, 163950, 176876, 607785, 163955

Functions and classifications

GOC:cytosol, C:mitochondrion, C:nucleus, C:protein complex, F:non-membrane spanning protein tyrosine phosphatase activity, F:SH3/SH2 adaptor activity, P:activation of MAPK activity, P:atrioventricular canal development, P:axon guidance, P:blood coagulation, P:brain development, P:DNA damage checkpoint, P:ephrin receptor signaling pathway, P:epidermal growth factor receptor signaling pathway, P:face morphogenesis, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:genitalia development, P:glucose homeostasis, P:hormone metabolic process, P:hormone-mediated signaling pathway, P:inner ear development, P:insulin receptor signaling pathway, P:interferon-gamma-mediated signaling pathway, P:leukocyte migration, P:multicellular organismal reproductive process, P:negative regulation of cortisol secretion, P:negative regulation of growth hormone secretion, P:negative regulation of insulin secretion, P:neurotrophin TRK receptor signaling pathway, P:organ growth, P:phosphatidylinositol-mediated signaling, P:positive regulation of glucose import in response to insulin stimulus, P:positive regulation of hormone secretion, P:regulation of cell adhesion mediated by integrin, P:regulation of interferon-gamma-mediated signaling pathway, P:regulation of multicellular organism growth, P:regulation of protein export from nucleus, P:regulation of type I interferon-mediated signaling pathway, P:T cell costimulation, P:triglyceride metabolic process, P:type I interferon signaling pathway, F:protein tyrosine phosphatase activity, P:axonogenesis, P:peptidyl-tyrosine dephosphorylation, P:nerve growth factor receptor signaling pathway, P:type I interferon-mediated signaling pathway
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Deafness, Disease mutation, Hydrolase, Phosphoprotein, Protein phosphatase, Reference proteome, Repeat, SH2 domain
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.530.00538RNA microarray19698090
Exp23671862aMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)0.16< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp23671862bMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)2.95< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.441.39E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.486.92E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium