CKDdb-logoCKDdb - Molecule ID A0008

geneCALM1, CALM2, CALM3
nameCalmodulin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CALM_HUMANP62158ENSP00000272298801Hs.282410114180, 114182, 114183, 614916

Functions and classifications

GOC:centrosome, C:cytosol, C:extracellular region, C:growth cone, C:nucleoplasm, C:plasma membrane, C:sarcomere, C:spindle microtubule, C:spindle pole, F:calcium ion binding, F:nitric-oxide synthase regulator activity, F:protein phosphatase activator activity, P:activation of adenylate cyclase activity, P:activation of phospholipase C activity, P:detection of calcium ion, P:epidermal growth factor receptor signaling pathway, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:glucose metabolic process, P:glycogen catabolic process, P:innate immune response, P:inositol phosphate metabolic process, P:muscle contraction, P:negative regulation of ryanodine-sensitive calcium-release channel activity, P:neurotrophin TRK receptor signaling pathway, P:nitric oxide metabolic process, P:platelet activation, P:platelet degranulation, P:positive regulation of cyclic nucleotide metabolic process, P:positive regulation of cyclic-nucleotide phosphodiesterase activity, P:positive regulation of nitric-oxide synthase activity, P:positive regulation of phosphoprotein phosphatase activity, P:positive regulation of protein dephosphorylation, P:positive regulation of ryanodine-sensitive calcium-release channel activity, P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, P:regulation of cell communication by electrical coupling involved in cardiac conduction, P:regulation of cytokinesis, P:regulation of heart rate, P:regulation of high voltage-gated calcium channel activity, P:regulation of nitric-oxide synthase activity, P:regulation of rhodopsin mediated signaling pathway, P:response to amphetamine, P:response to corticosterone, P:rhodopsin mediated signaling pathway, P:synaptic transmission, C:cytoplasm, C:nucleus, P:calcium-mediated signaling, P:regulation of ryanodine-sensitive calcium-release channel activity, F:kinase activity, P:G-protein coupled receptor signaling pathway, P:nerve growth factor receptor signaling pathway, P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, P:response to calcium ion, P:small molecule metabolic process
UniProt3D-structure, Acetylation, Calcium, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Isopeptide bond, Metal-binding, Methylation, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Ubl conjugation, Kinase, Transferase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.273.23E-06RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)2.640hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.04 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)2.24 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)2.24 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.467.37E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium