PADB-logoLSSR - molecule cluster A9701CUL3Cullin homolog 3

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCUL3_HUMANQ1361876888930603136, 614496

Functions and Classifications

GOC:Cul3-RING ubiquitin ligase complex, C:Golgi membrane, C:nucleus, C:polar microtubule, F:POZ domain binding, P:cell cycle arrest, P:cell migration, P:COPII vesicle coating, P:cyclin catabolic process, P:cytokinesis, P:embryonic cleavage, P:G1/S transition of mitotic cell cycle, P:gastrulation, P:integrin-mediated signaling pathway, P:intrinsic apoptotic signaling pathway, P:mitotic anaphase, P:negative regulation of Rho protein signal transduction, P:positive regulation of cell proliferation, P:positive regulation of cytokinesis, P:protein monoubiquitination, P:protein polyubiquitination, P:stem cell division, P:stress fiber assembly, P:trophectodermal cellular morphogenesis, P:Wnt signaling pathway, C:cullin-RING ubiquitin ligase complex, P:ubiquitin-dependent protein catabolic process, C:Golgi apparatus, P:Wnt receptor signaling pathway
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Disease mutation, ER-Golgi transport, Golgi apparatus, Isopeptide bond, Nucleus, Polymorphism, Reference proteome, Transport, Ubl conjugation, Ubl conjugation pathway, Phosphoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
2914141400000002900

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16684767humanbloodplasma severe trauma     Identified peptides: 1
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.11 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 99
16861337humanblooderythrocytenuclear and golgihealthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   2.26 
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative