PADB-logoLSSR - molecule cluster A834BARF6ADP-ribosylation factor 6

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensARF6_HUMANP6233017419951600464

Functions and Classifications

GOC:cell cortex, C:cleavage furrow, C:early endosome, C:endocytic vesicle, C:filopodium membrane, C:Golgi apparatus, C:midbody, C:recycling endosome membrane, C:ruffle, F:GTP binding, F:GTPase activity, P:cell adhesion, P:cell cycle, P:cell division, P:cellular component movement, P:cortical actin cytoskeleton organization, P:establishment of epithelial cell polarity, P:hepatocyte apoptotic process, P:liver development, P:myeloid cell apoptotic process, P:negative regulation of receptor-mediated endocytosis, P:positive regulation of actin filament polymerization, P:positive regulation of establishment of protein localization to plasma membrane, P:protein localization to cell surface, P:protein localization to endosome, P:protein transport, P:regulation of dendritic spine development, P:regulation of filopodium assembly, P:regulation of Rac protein signal transduction, P:ruffle organization, P:small GTPase mediated signal transduction, P:vesicle-mediated transport, C:intracellular, C:endosome, C:endosome membrane, C:recycling endosome, P:apoptotic process
UniProt3D-structure, Cell cycle, Cell division, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Differentiation, Endosome, ER-Golgi transport, Golgi apparatus, GTP-binding, Lipoprotein, Membrane, Myristate, Neurogenesis, Nucleotide-binding, Protein transport, Reference proteome, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.42   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
21113216000000001111

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16709260humansemenplasma healthy     
16446289humanhairshaft healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.055 
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17000643ratliverinner mitochondrial membrane healthy     
16615899mouseliverorganelleNucleushealthy     
15326289humanurineexosomecytoplasm (endosomal trafficking) healthy     
18373357humanurinemicroparticles bladder cancer   1.3 
21127740humanurinewhole acute abdominal pain     Identified peptides: 49
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative