PADB-logoLSSR - molecule cluster A7495PPT1, PPTPalmitoyl-protein thioesterase 1 precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPPT1_HUMANP5089730634193256730, 600722

Functions and Classifications

GOC:axon, C:cytosol, C:dendrite, C:extracellular region, C:extracellular space, C:Golgi apparatus, C:lysosome, C:membrane raft, C:neuronal cell body, C:nucleus, C:synaptic vesicle, F:palmitoyl-(protein) hydrolase activity, F:palmitoyl-CoA hydrolase activity, P:adult locomotory behavior, P:apoptotic DNA fragmentation, P:associative learning, P:brain development, P:cellular protein catabolic process, P:cofactor metabolic process, P:cofactor transport, P:grooming behavior, P:lysosomal lumen acidification, P:membrane raft organization, P:negative regulation of cell growth, P:negative regulation of neuron apoptotic process, P:neuron development, P:neurotransmitter secretion, P:pinocytosis, P:positive regulation of pinocytosis, P:positive regulation of receptor-mediated endocytosis, P:protein depalmitoylation, P:protein transport, P:receptor-mediated endocytosis, P:regulation of phospholipase A2 activity, P:regulation of synapse structure and activity, P:sphingolipid catabolic process, P:visual perception, P:lysosome organization, P:cellular protein modification process
UniProt3D-structure, Alternative splicing, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Lysosome, Neurodegeneration, Neuronal ceroid lipofuscinosis, Polymorphism, Reference proteome, Sensory transduction, Signal, Vision
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
129119220049332016

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18361515humansalivaSMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
21127740humanurinewhole acute abdominal pain     Identified peptides: 13
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     

Compile date 12-23-2014© PADB initiative