PADB-logoLSSR - molecule cluster A7403PCMT1Protein-L-isoaspartate (D-aspartate) O-methyltransferase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPIMT_HUMANP2206122724636176851

Functions and Classifications

GOC:endoplasmic reticulum, F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity, P:protein repair, P:protein methylation, C:cytoplasm, P:S-adenosylhomocysteine metabolic process, P:S-adenosylmethionine metabolic process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, Methyltransferase, Polymorphism, Reference proteome, S-adenosyl-L-methionine, Transferase
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
2224281400010000020

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 2
16709260humansemenplasma healthy     
18361515humansalivaParotid healthy     Identified peptides: 4
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 2
15852343ratbrainPSD cerebral cortex (frontal) healthy     
21616181mousecornea  lumican knock-out   1.1 
16861337humanblooderythrocytecytoplasmichealthy     
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 4
16609934humanheartleft ventricle healthy     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
15951573humanlungbronchoalveolar lavage asthma     
15064947humantestiswhole healthy     
17881425mouseurinewhole Focal segmental glomerulosclerosis (FSGS)     
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 6

Compile date 12-23-2014© PADB initiative