PADB-logoLSSR - molecule cluster A7390PCBD1, DCOH, PCBDPterin-4-alpha-carbinolamine dehydratase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPHS_HUMANP6145710311868126090, 264070

Functions and Classifications

GOC:cytosol, C:nucleus, F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity, F:phenylalanine 4-monooxygenase activity, F:transcription coactivator activity, P:cellular nitrogen compound metabolic process, P:L-phenylalanine catabolic process, P:oxidation-reduction process, P:positive regulation of transcription, DNA-templated, P:protein heterooligomerization, P:protein homotetramerization, P:regulation of protein homodimerization activity, P:tetrahydrobiopterin biosynthetic process, P:transcription, DNA-templated, "C:nucleus, P:tetrahydrobiopterin biosynthetic process", P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent"
UniProtAcetylation, Activator, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Lyase, Nucleus, Reference proteome, Tetrahydrobiopterin biosynthesis, Transcription, Transcription regulation
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
60110172260116111100

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexNucleushealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18167449ratkidneywhole diabetes   1.45 
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
21127740humanurinewhole acute abdominal pain     Identified peptides: 3
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     
18553995humanprostatewhole prostate cancer     Identified peptides: 2
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative