PADB-logoLSSR - molecule cluster A6792IMPA1, IMPAInositol(myo)-1(or 4)-monophosphatase 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensIMPA1_HUMANP2921827730189602064

Functions and Classifications

GOC:cytosol, C:mitochondrion, C:nucleus, F:inositol monophosphate 1-phosphatase activity, F:inositol monophosphate 3-phosphatase activity, F:inositol monophosphate 4-phosphatase activity, F:metal ion binding, P:inositol biosynthetic process, P:inositol phosphate dephosphorylation, P:phosphatidylinositol biosynthetic process, P:phosphatidylinositol phosphorylation, P:signal transduction, C:axon, C:neuronal cell body, P:response to lithium ion
UniProt3D-structure, Alternative splicing, Complete proteome, Cytoplasm, Hydrolase, Lithium, Magnesium, Metal-binding, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000001000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.13 
14720225ratbrainPSD forebrain healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 3
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 3
17436268mousekidneycortex diabetes   2.6 
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
15064947humantestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 1
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative