PADB-logoLSSR - molecule cluster A5982CTSB, CPSB, APPSCathepsin B precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCATB_HUMANP0785833937808116810

Functions and Classifications

GOC:endolysosome lumen, C:extracellular space, C:melanosome, C:mitochondrion, C:nucleolus, C:perinuclear region of cytoplasm, F:cysteine-type endopeptidase activity, P:cellular response to thyroid hormone stimulus, P:collagen catabolic process, P:extracellular matrix disassembly, P:innate immune response, P:proteolysis, P:regulation of apoptotic process, P:regulation of catalytic activity, P:toll-like receptor signaling pathway, F:cysteine-type peptidase activity, C:lysosome, P:metabolic process, C:apical plasma membrane, C:caveola, C:external side of plasma membrane, C:sarcolemma, F:peptide binding, P:autophagy, P:negative regulation of cell death, P:response to amine stimulus, P:response to ethanol, P:response to glucose stimulus, P:response to interleukin-4, P:response to mechanical stimulus, P:response to organic cyclic compound, P:response to peptide hormone stimulus, P:response to wounding, P:skeletal muscle tissue development
UniProt3D-structure, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Lysosome, Polymorphism, Protease, Reference proteome, Secreted, Signal, Thiol protease, Zymogen
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
2.8   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
1053117015412356

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 23
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.3 
16609934humanheartleft ventricle healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
15047867ratliverGolgi healthy     Sequence coverage: 20.4
16691549ratliverGolgi healthy      
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
16518875humannasalnasal cellsLysosomescystic fibrosis   0.633 
17022654humanurinewhole healthy     
15048996humanurinewholevesicular/Lysosomalhealthy     
16372274humanurinewholeLysosomeImmunoglobulin A nephropathy (IgAN)   0.25 
18440303raturineglycoproteins glomerular disease/adriamycin nephropathy and Thy1.1 glomerulonephritis   0.50
16335936humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 11
UNPUBLISHED_1humanurinewhole healthy, cancer     
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 4
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative