PADB-logoLSSR - molecule cluster A4856HSPB1, HSP27, HSP28Heat shock protein beta-1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensHSPB1_HUMANP0479220522783602195, 606595, 608634

Functions and Classifications

GOC:cytoskeleton, C:cytosol, C:nucleus, C:plasma membrane, C:proteasome complex, C:spindle, C:Z disc, F:protein kinase C binding, F:protein kinase C inhibitor activity, F:ubiquitin binding, P:cell death, P:cellular component movement, P:gene expression, P:intracellular signal transduction, P:mRNA metabolic process, P:negative regulation of apoptotic process, P:negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress, P:positive regulation of angiogenesis, P:positive regulation of blood vessel endothelial cell migration, P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway, P:positive regulation of interleukin-1 beta production, P:positive regulation of tumor necrosis factor biosynthetic process, P:regulation of I-kappaB kinase/NF-kappaB signaling, P:regulation of translational initiation, P:response to unfolded protein, P:response to virus, P:negative regulation of protein serine/threonine kinase activity, C:cell surface, P:intracellular protein kinase cascade, P:regulation of I-kappaB kinase/NF-kappaB cascade
UniProt3D-structure, Acetylation, Chaperone, Charcot-Marie-Tooth disease, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Neurodegeneration, Neuropathy, Nucleus, Phosphoprotein, Reference proteome, Stress response
PADBCHA: chaperone, chaperonin

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000001388

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 3
16709260humansemenplasma healthy     
17381150humannasalolfactory cleft mucus (nasal mucus) healthy     
16901338humantearwhole healthy     
16446289humanhairshaft healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 1
15253431humanheartmitochondria healthy     Unique peptides: 3
21616181mousecornea  lumican knock-out   1.095 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 3
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
16609934humanheartleft ventricle healthy     
12724530humanHela cell extractlipid raftsdetergent-resistant raft; Raft-associated protein; Membrane proteinhealthy      
15668995humankidneycortex healthy     
15668995humankidneycortex healthy     
15668995humankidneycortex healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
17123452humankidneywhole renal cell carcinoma  up2.4 +/- 0.4 
12965894ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts     
14532164ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat     
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16641100ratkidneyinner medullary collecting duct (IMCD) Phosphoproteome of IMCD     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
15951573humanlungbronchoalveolar lavage asthma     
16083270humanlungwhole smoker     
15378748mouselungbronchoalveolar lavage asthma (dex-sensitised and challenged)   1 
16518875humannasalnasal cellsCytoplasm, nucleus (HS response)cystic fibrosis   0.56 
16021519humanovarywhole healthy     
16021519humanovarywhole healthy     
18334958humantearwholecytoplasmhealthy      
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
16335936humanurinewhole healthy     
18373357humanurinemicroparticles bladder cancer   2 
21127740humanurinewhole acute abdominal pain     Identified peptides: 160
UNPUBLISHED_1humanurinewhole healthy, cancer     
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 5
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 8
16457607ratheartleft ventricles spontaneous hypertension  up2.2??0.29? 
16457607ratheartleft ventricles spontaneous hypertension  up5.8??1.87 
16457607ratheartleft ventricles spontaneous hypertension  down-2.7??0.06? 
16457607ratheartleft ventricles spontaneous hypertension  up3.3??0.69 
22659219ratheartwhole heart heart failure   2.21  
22659219ratheartwhole heart heart failure   1.18  

Compile date 12-23-2014© PADB initiative