PADB-logoLSSR - molecule cluster A336ADDB1, XAP1DNA damage binding protein 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensDDB1_HUMANQ165311140126967600045

Functions and Classifications

GOC:Cul4A-RING ubiquitin ligase complex, C:Cul4B-RING ubiquitin ligase complex, C:cytoplasm, C:nucleoplasm, F:damaged DNA binding, P:nucleotide-excision repair, DNA damage removal, P:proteasome-mediated ubiquitin-dependent protein catabolic process, P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:regulation of mitotic cell cycle phase transition, P:viral process, P:Wnt signaling pathway, P:Wnt signaling pathway, C:nucleus, F:nucleic acid binding, P:cell cycle checkpoint, P:proteasomal ubiquitin-dependent protein catabolic process, P:virus-host interaction, P:Wnt receptor signaling pathway", P:Wnt receptor signaling pathway
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, DNA damage, DNA repair, DNA-binding, Host-virus interaction, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Ubl conjugation, Ubl conjugation pathway
PADBTF: transcription and translation, gene regulation

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
1.7   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0670000033000000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16684767humanbloodplasma severe trauma     Identified peptides: 2
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.885 
16861337humanblooderythrocytenuclearhealthy     
16381850humanHela cell extractnucleus healthy     theoretical Mr: 128918
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.81 
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 7
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative