PADB-logoLSSR - molecule cluster A330CRAB5C, RABLRas-related protein Rab-5C

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensRAB5C_HUMANP5114821623483604037

Functions and Classifications

GOC:early endosome membrane, C:endocytic vesicle, C:lipid particle, C:lysosomal membrane, C:melanosome, C:plasma membrane, F:GDP binding, F:GTP binding, F:GTPase activity, P:endosome organization, P:protein transport, P:regulation of endocytosis, P:small GTPase mediated signal transduction
UniProtAlternative splicing, Cell membrane, Complete proteome, Endosome, GTP-binding, Lipoprotein, Membrane, Nucleotide-binding, Polymorphism, Prenylation, Protein transport, Reference proteome, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
1517114114046107811

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.04 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 99
16861337humanblooderythrocyteinner surface of plasma membrane, Plasma membrane-associatedhealthy     Identified peptides: 10
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 5
12724530humanHela cell extractlipid raftspH-resistant rafthealthy      
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17711322humankidneyglomerulus healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
17768142mousekidneyperoxisomeunknownhealthy     
17768142mousekidneyperoxisomal membraneunknownhealthy     
16691549ratliverGolgi healthy      
16691549ratliverGolgi healthy      
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15326289humanurineexosomecytoplasm (endosomal trafficking) healthy     
8330623humanurineexosomecytoplasm (endosomal trafficking) healthy     
18373357humanurinemicroparticles bladder cancer   1.3 
21127740humanurinewhole acute abdominal pain     Identified peptides: 75
UNPUBLISHED_1humanurinewhole healthy     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1 
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 5

Compile date 12-23-2014© PADB initiative