PADB-logoLSSR - molecule cluster A2481ARSAArylsulfatase A precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensARSA_HUMANP1528950753588250100, 272200, 607574

Functions and Classifications

GOC:acrosomal vesicle, C:endoplasmic reticulum lumen, C:endosome, C:extracellular space, C:extrinsic component of external side of plasma membrane, C:integral component of membrane, C:lysosomal lumen, F:arylsulfatase activity, F:calcium ion binding, F:cerebroside-sulfatase activity, P:autophagy, P:binding of sperm to zona pellucida, P:central nervous system development, P:glycosphingolipid metabolic process, P:post-translational protein modification, P:response to estrogen, P:response to ethanol, P:response to methylmercury, P:response to nutrient, P:response to pH, P:small molecule metabolic process, F:sulfuric ester hydrolase activity, C:plasma membrane, P:phospholipid metabolic process
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Ichthyosis, Leukodystrophy, Lysosome, Metachromatic leukodystrophy, Metal-binding, Polymorphism, Reference proteome, Signal
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
18000000000003250

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16316981humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 2
16709260humansemenplasma healthy     
18361515humansalivaParotid healthy     Identified peptides: 3
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15048996humanurinewholevesicular/Lysosomalhealthy     
15048996humanurinewholevesicular/Lysosomalhealthy     
16281181humanurinewhole healthy     
16281181humanurinewhole healthy     
16281181humanurinewhole healthy     
17518487humanurinewholelysosome bladder cancer     
16335936humanurinewhole healthy     
17258946humanurineglycoproteomeLysosomalhealthyMetachromatic Leukodystrophy   
21127740humanurinewhole acute abdominal pain     Identified peptides: 31
UNPUBLISHED_1humanurinewhole healthy, cancer     
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative