PADB-logoLSSR - molecule cluster A1702AGT, SERPINA8Angiotensinogen

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensANGT_HUMANP0101948553154106150, 145500, 267430

Functions and Classifications

GOC:extracellular space, F:growth factor activity, F:hormone activity, F:serine-type endopeptidase inhibitor activity, P:activation of NF-kappaB-inducing kinase activity, P:activation of phospholipase C activity, P:aging, P:angiotensin maturation, P:angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure, P:angiotensin-mediated drinking behavior, P:artery smooth muscle contraction, P:astrocyte activation, P:blood vessel development, P:blood vessel remodeling, P:branching involved in ureteric bud morphogenesis, P:catenin import into nucleus, P:cell growth involved in cardiac muscle cell development, P:cell-cell signaling, P:cell-matrix adhesion, P:cellular lipid metabolic process, P:cellular protein metabolic process, P:cellular response to mechanical stimulus, P:cellular sodium ion homeostasis, P:cytokine secretion, P:ERK1 and ERK2 cascade, P:establishment of blood-nerve barrier, P:excretion, P:extracellular matrix organization, P:fibroblast proliferation, P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, P:kidney development, P:low-density lipoprotein particle remodeling, P:negative regulation of angiogenesis, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of neuron apoptotic process, P:negative regulation of neurotrophin TRK receptor signaling pathway, P:negative regulation of tissue remodeling, P:nitric oxide mediated signal transduction, P:ovarian follicle rupture, P:peristalsis, P:phospholipase C-activating G-protein coupled receptor signaling pathway, P:positive regulation of activation of JAK2 kinase activity, P:positive regulation of branching involved in ureteric bud morphogenesis, P:positive regulation of cardiac muscle hypertrophy, P:positive regulation of cholesterol esterification, P:positive regulation of cytokine production, P:positive regulation of endothelial cell migration, P:positive regulation of epidermal growth factor receptor signaling pathway, P:positive regulation of extracellular matrix constituent secretion, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of fibroblast proliferation, P:positive regulation of inflammatory response, P:positive regulation of macrophage derived foam cell differentiation, P:positive regulation of MAPK cascade, P:positive regulation of multicellular organism growth, P:positive regulation of NAD(P)H oxidase activity, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of organ growth, P:positive regulation of phosphatidylinositol 3-kinase signaling, P:positive regulation of protein tyrosine kinase activity, P:positive regulation of reactive oxygen species metabolic process, P:positive regulation of renal sodium excretion, P:positive regulation of superoxide anion generation, P:positive regulation of transcription, DNA-templated, P:regulation of blood vessel size by renin-angiotensin, P:regulation of calcium ion transport, P:regulation of cell growth, P:regulation of long-term neuronal synaptic plasticity, P:regulation of norepinephrine secretion, P:regulation of proteolysis, P:regulation of renal output by angiotensin, P:regulation of renal sodium excretion, P:regulation of vasoconstriction, P:renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure, P:renin-angiotensin regulation of aldosterone production, P:response to cold, P:response to muscle activity involved in regulation of muscle adaptation, P:response to salt stress, P:small molecule metabolic process, P:smooth muscle cell differentiation, P:smooth muscle cell proliferation, P:stress-activated MAPK cascade, P:uterine smooth muscle contraction, P:vasodilation, C:extracellular space, P:regulation of systemic arterial blood pressure by renin-angiotensin, P:G-protein coupled receptor signaling pathway, P:hormone metabolic process, P:positive regulation of gene expression, P:regulation of inflammatory response, P:vasodilation, "C:cytoplasmic part, F:acetyltransferase activator activity, P:induction of apoptosis, P:negative regulation of nerve growth factor receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of phosphatidylinositol 3-kinase cascade, P:positive regulation of transcription, DNA-dependent, C:cytoplasmic part
UniProt3D-structure, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Polymorphism, Reference proteome, Secreted, Signal, Vasoactive, Vasoconstrictor
PADBSIG: signalling

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
17494094humanurinewhole healthy; Dent's disease, X-linked form of renal Fanconi syndrome; Lowe disease, X-linked form of renal Fanconi syndrome     
16316981humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 65
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18361515humansalivaParotid;SMSL healthy     
17627911ratbloodserum bone loss model (associated with extended bed rest or space travel) by Hindlimb unloading   1.42 
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
15951573humanlungbronchoalveolar lavage asthma     
15951573humanlungbronchoalveolar lavage asthma     
11680902humanurinewhole healthy     
17327332humanurinewhole Diabetic Nephropathy     
17494094humanurinewhole healthy; tubular proteinuria (TP), X-linked form of renal Fanconi syndrome; Dent's disease, X-linked form of renal Fanconi syndrome; Lowe disease, X-linked form of renal Fanconi syndrome; autosomal dominant idiopathic form (ADIF) of renal Fanconi syndrome   2.67 
15140760humanurinewhole Dent's disease   >1 
16335936humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 90
UNPUBLISHED_1humanurinewhole healthy, cancer     
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative