PADB-logoLSSR - molecule cluster A1292UBE2N, BLUUbiquitin-conjugating enzyme E2 N

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensUBE2N_HUMANP6108815217138603679

Functions and Classifications

GOC:cytosol, C:nucleus, C:UBC13-MMS2 complex, C:UBC13-UEV1A complex, C:ubiquitin ligase complex, F:ATP binding, F:ubiquitin binding, F:ubiquitin-protein ligase activity, P:cytokine-mediated signaling pathway, P:DNA double-strand break processing, P:double-strand break repair via homologous recombination, P:Fc-epsilon receptor signaling pathway, P:histone ubiquitination, P:innate immune response, P:MyD88-dependent toll-like receptor signaling pathway, P:nucleotide-binding oligomerization domain containing signaling pathway, P:positive regulation of DNA repair, P:positive regulation of histone modification, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of ubiquitin-protein ligase activity, P:postreplication repair, P:protein K63-linked ubiquitination, P:proteolysis, P:regulation of histone ubiquitination, P:T cell receptor signaling pathway, P:toll-like receptor 10 signaling pathway, P:toll-like receptor 2 signaling pathway, P:toll-like receptor 4 signaling pathway, P:toll-like receptor 5 signaling pathway, P:toll-like receptor 9 signaling pathway, P:toll-like receptor TLR1:TLR2 signaling pathway, P:toll-like receptor TLR6:TLR2 signaling pathway, P:ubiquitin-dependent protein catabolic process, F:acid-amino acid ligase activity, P:metabolic process, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:Toll signaling pathway, P:toll-like receptor 1 signaling pathway
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, DNA damage, DNA repair, Isopeptide bond, Ligase, Nucleotide-binding, Nucleus, Reference proteome, Ubl conjugation, Ubl conjugation pathway
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
10, 1414, 1727, 1720, 190, 00, 00, 00, 05, 80, 05, 80, 012, 117, 6

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 2
21616181mousecornea  lumican knock-out   1.115 
16861337humanblooderythrocytecytoplasmichealthy     
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 4
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 2
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleMitochondrion (Mito)|Cytosol (Cyto)healthy     
16615899mouseliverorganelleCytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
15326289humanurineexosomecytoplasm (endosomal trafficking) healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 12
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative