PADB-logoLSSR - molecule cluster A0370LDHA, PIG19L-lactate dehydrogenase A chain

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensLDHA_HUMANP0033833136557150000, 612933

Functions and Classifications

GOC:cilium, C:cytosol, C:mitochondrion, F:L-lactate dehydrogenase activity, P:cellular carbohydrate metabolic process, P:cellular response to extracellular stimulus, P:glycolysis, P:pyruvate metabolic process, "F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, P:cellular carbohydrate metabolic process", C:cytoplasm, C:flagellum, F:nucleotide binding, "F:nucleotide binding, F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Glycogen storage disease, Glycolysis, NAD, Oxidoreductase, Phosphoprotein, Polymorphism, Reference proteome, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
22   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
34541700712712514

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 10
16709260humansemenplasma healthy     
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
16446289humanhairshaft healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.985 
16861337humanblooderythrocytecytoplasmichealthy     
9371836pigbrainPSD healthy      
10862698mousebrainNMDA-receptor co-IP, PDZ-affinity peptide (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 4
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 9
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 14.2
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant raft; Raft-associated protein; Membrane proteinhealthy      
16381850humanHela cell extractnucleus healthy     theoretical Mr: 36950
12965894ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   1.04 0.03 
16449382ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts   2.03 0.14 
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17768142mousekidneyperoxisomecytoplasmichealthy     
17768142mousekidneyperoxisomecytoplasmichealthy     
17768142mousekidneyperoxisomecytoplasmichealthy     
17768142mousekidneyperoxisomecytoplasmichealthy     
17711322humankidneyglomerulus healthy     
15047867ratliverGolgi healthy     Sequence coverage: 23.5
17000643ratliverinner mitochondrial membrane healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganellePlasma membrane (PM)|Cytosol (Cyto)healthy     
16622028mouselungbronchoalveolar lavage asthma (OVA-sensitised and challenged)     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
18334958humantearwholecytoplasmhealthy      
15326289humanurineexosomecytoplasmhealthy     
11487543humanurineexosomecytoplasmhealthy     
16335936humanurinewhole healthy     
18373357humanurinemicroparticles bladder cancer   1.5 
21127740humanurinewhole acute abdominal pain     Identified peptides: 206
21538913humanurinewhole cancer (upper GI)     
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.73 
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 7
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 6

Compile date 12-23-2014© PADB initiative